Persistent Thalamic Sound Processing Despite Profound Cochlear Denervation
نویسندگان
چکیده
منابع مشابه
Persistent Thalamic Sound Processing Despite Profound Cochlear Denervation
Neurons at higher stages of sensory processing can partially compensate for a sudden drop in peripheral input through a homeostatic plasticity process that increases the gain on weak afferent inputs. Even after a profound unilateral auditory neuropathy where >95% of afferent synapses between auditory nerve fibers and inner hair cells have been eliminated with ouabain, central gain can restore c...
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Cochlear implants are devices designed to provide a measure of hearing to the deaf. Most deaf individuals have lost the ability to translate sound into the patterns of electric activity normally present on the 30,000 fibers of the auditory nerve. Because these patterns of activity are the inputs to the brain that result in sound sensation, cochlear implants deliver electric stimuli to these fib...
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The aim of this study was to evaluate the Differential-Rate Sound Processing (DRSP) strategy for speech perception by users of the Nucleus cochlear implant. The DRSP strategy uses both low and high rates of stimulation – applying a low rate of stimulation to apical, lower-frequency electrodes and a high rate of stimulation to basal, higher-frequency electrodes. Ten patients implanted with the N...
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Sensory organ damage induces a host of cellular and physiological changes in the periphery and the brain. Here, we show that some aspects of auditory processing recover after profound cochlear denervation due to a progressive, compensatory plasticity at higher stages of the central auditory pathway. Lesioning >95% of cochlear nerve afferent synapses, while sparing hair cells, in adult mice virt...
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ژورنال
عنوان ژورنال: Frontiers in Neural Circuits
سال: 2016
ISSN: 1662-5110
DOI: 10.3389/fncir.2016.00072